There are several video games based on the film. Atlantis The Lost Empire: Search for the Journal (commonly known as Atlantis: Search for the Journal) was developed by Zombie Studios and published by Buena Vista Games, a subsidiary of Disney Interactive. It was released on May 1, 2001, for the Microsoft Windows platform and was a first-person shooter game, the first of two games based on the film developed by Zombie Studios and released for UPC labels from Kellogg's products for promotion.[123][124] Atlantis: The Lost Empire—Trial by Fire (commonly known as Atlantis: Trial by Fire) was the second game developed by Zombie Studios and published by Disney Interactive, and was released May 18, 2001, for the Microsoft Windows platform.[125]Atlantis: The Lost Empire is an action game developed by Eurocom for the PlayStation console which was released June 14, 2001. The player controls Milo, Audrey, Molière, Kida and Vinny as they traverse Atlantis, unlocking its secrets. Some features in the game unlock others (such as a movie) by finding items hidden throughout the game. THQ released Disney's Atlantis: The Lost Empire for the Game Boy Advance and Game Boy Color. It is a platform game in which the player controls Milo and three other characters from the film across 14 levels on a quest to discover Atlantis. The game was met with average to mixed reviews upon release. GameRankings and Metacritic gave it a score of 74% and 73 out of 100 for the PlayStation version;[107][110] 65% for the Game Boy Color version;[108] and 56% and 51 out of 100 for the Game Boy Advance version.

Bishi Bashi (ビシバシチャンプ Bishi Bashi Chanpu) is a series of Konami video games for arcades, mobile phones, PlayStation and Windows. All games in the series comprise playing through a wide variety of competitive minigames against other players. The arcade games support 1 to 6 players and the PlayStation game allows 1 to 8 players; the game will provide computer opponents if there are not enough players.

C-12: Final Resistance is a video game developed by SCE Studio Cambridge for the PlayStation. It was released in Europe on April 6, 2001 and in North America on July 22, 2002. It also came on a Twin Pack CD bundled with MediEvil in 2003.The story is set in the future, as aliens have invaded in an attempt to harvest all of Earth's carbon resources (C-12 is a reference to 12C, the most abundant Isotopes of carbon). The player uses Lieutenant Riley Vaughan, a cybernetic human soldier, and member of the underground resistance. The player undertakes missions played out in a third-person view, killing aliens and cyborgs, collecting weapons and keys, and the like.

Creatures is an artificial life (alife) computer program series, created in the mid-1990s by English computer scientist Steve Grand whilst working for the Cambridge video games developer Millennium Interactive. Gameplay focuses on raising alien creatures known as Norns, teaching them to survive, helping them explore their world, defending them against other species, and breeding them. Words can be taught to creatures by a learning computer (for verbs) or by repeating the name of the object while the creature is looking at it. After a creature understands language, the player can instruct their creature by typing in instructions, which the creature may choose to obey. A complete life cycle is modelled for the creatures - childhood, adolescence, adulthood, and senescence, each with their own particular needs. The gameplay is designed to foster an emotional bond between the player and their creatures. Rather than taking a scripted approach, Creatures series games were driven by detailed biological and neurological simulation and their unexpected results. There were six major Creatures releases from Creature Labs. Between 1996 and 2001, there were three principal games released, the Docking Station add-on (generally referenced as a separate game) and two children's games, and there were three games created for console systems. A sequel named Creatures Online was in development, with the artificial life technology from Creatures 3 and Docking Station updated to a 3D environment.